Fig. 4.

IL-1β maturation and renal fibrosis were alleviated by caspase-11 siRNA in obstructed kidneys. Mice were subjected to UUO induction for 14 days (n = 6). UUO mice received caspase-11 siRNA (0.5 nmol/g) for 14 days. a Western blot of pro-caspase-11. b Representative western blot quantification of pro-caspase-11. c Representative western blot of TGF-β, fibronectin, and collagen I. d Quantification of TGF-β, fibronectin, and collagen I. e Representative western blot of pro-caspase-1, caspase-1, pro-IL-1β, and IL-1β. f Quantification of pro-caspase-1, caspase-1, pro-IL-1β, and IL-1β. All values are presented as the mean ± SEM (n = 6). ^*P < 0.05 versus sham + NC siRNA. ^#P < 0.05 versus UUO + NC siRNA