Fig. 7.

HOTAIR and FGFR1 were upregulated in PCa bone metastatic tissues. a Representative ISH images of HOTAIR are shown. HOTAIR expression (shown by the black arrow) in bone metastatic tissues was significantly higher than in the expression in the matched primary PCa tissues (ISH, 400×, n = 40). b Similar to the HOTAIR expression levels, bone metastatic tissues had a significantly higher FGFR1 expression level (shown by the black arrow) than that in the matched primary PCa tissues (IHC, 400×, n = 40). c The serum HOTAIR expression level was positively associated with the levels of bone metabolic markers in PCa patients (P < 0.05, n = 80). d The ROC curves of the serum HOTAIR and bone metabolic marker levels are shown