Fig. 5.

MLB inhibits LPS-induced NF-κB activation in vitro and in vivo. a Effects of MLB on LPS-induced Ser536 phosphorylation of p65 and IκBα degradation. HMEC-1 cells were pretreated with 100 μM MLB for 12 h and then stimulated with 1 μg/mL LPS for 0.5 h. Data are expressed as means ± SEM of five independent experiments. b Lung and aorta expression of IκBα protein in the control, LPS-only and 100 mg/kg MLB + LPS groups. Data are expressed as means ± SEM, n = 5 animals/group (*P < 0.05, **P < 0.01, ***P < 0.001)