Fig. 2.

Olanzapine (OLZ) treatment promoted lipid accumulation in the rat liver, whereas cotreatment with simvastatin (Sim) reduced the lipid accumulation induced by OLZ. a (1–4): Representative images counterstained with hematoxylin; b (1–4): (ORO)-stained histological sections of livers from rats treated with (a-1/b-1) the vehicle (Control), (a-2/b-2) OLZ, (a-3/b-3) Sim, (a-4/b-4), or OLZ + Sim. c Lipid levels in the liver. The ORO staining data are shown as the mean ± SEM. d Liver weights. ORO: oil red O. F: Lipid droplets in the liver sections of the different treatment groups. ^*P < 0.05, vs. control; ^#P < 0.05 vs. OLZ-only