Fig. 10.

NTZ reduced inflammation in APP/PS1 transgenic mice. a RT-PCR assay was used to assess the effects of NTZ on the transcription of inflammatory cytokines in APP/PS1 transgenic mice (one-way ANOVA, Dunnett’s multiple comparison test. n = 3. ^*P < 0.05; ^**P < 0.01; ^***P < 0.001 vs TV). b–c Protein levels of inflammatory cytokines in APP/PS1 transgenic mice were assessed by Western blot. c Quantitative results of (b). GAPDH was used as a loading control in Western blot assays (one-way ANOVA. n = 4. ^*P < 0.05; ^**P < 0.01 vs TV). NV, nontransgenic vehicle group, TV, transgenic vehicle group, NTZ, transgenic mice with NTZ administration (90 mg·kg⁻¹·d⁻¹) group. Values indicate the mean ± SEM