Fig. 6.
NTZ effectively improved learning and memory impairments in APP/PS1 transgenic mice. MWM test was used to evaluate the effect of NTZ on APP/PS1 transgenic mice. a Representative tracing graphs in the training trials. b Escape latency during platform trials (two-way ANOVA, n = 10. *P < 0.01; ***P < 0.001 compared with TV). c Representative tracing graphs in the probe trials. d Crossing times of the platform in the probe trials (one-way ANOVA, n = 10. *P < 0.01; ***P < 0.001 compared with TV). NV, nontransgenic vehicle group; TV, transgenic AD model vehicle group, NTZ, transgenic AD model with NTZ administration (90 mg·kg−1·d−1) group. Values indicate the mean ± SEM