Fig. 3.

Inhibition of c-Myc protects against I/R-induced renal injury. Control and I/R (24 h) rats received vehicle and 10058-F4 (12.5 mg/kg body weight), respectively, via oral gavage 6 h before I/R surgery and gavage every 6 h during reperfusion. a, b Serum creatinine and blood urea nitrogen were assayed using ELISA kit (six rats per group). c, d H&E and PAS were performed to visualize renal injury (six rats per group). Representative sections of H&E- and PAS-stained kidneys. Original magnification ×200 or ×400. Data are presented as the mean ± SEM. ^**P < 0.01 versus control, ^#P < 0.05 versus I/R