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Simulated volume expansions of the central fluid space (a) and peripheral fluid space (b) in a hypothetical patient receiving 10 mL/kg of Ringer’s lactate solution over 15 min followed by a rate of 8 mL/kg/h for 165 min. Based on the weight (40 vs. 80 kg) and mean arterial pressure (50 vs. 100 mmHg), four different cases were simulated. WT weight, MAP mean arterial pressure
