Table 3.
Population pharmacokinetic parameter estimates, inter-individual variability, and median parameter values (2.5%–97.5%) of the non-parametric bootstrap replicates of the final pharmacokinetic model for Ringer’s lactate solution
| Parameters | Estimates (RSE, %) | CV (%) | Median (2.5%–97.5%) | |
|---|---|---|---|---|
| kr (mL/min) = θ1 + (MAP/70)θ2 | 70.6 | |||
| θ1 | 124 (18.1) | 116 (90–149) | ||
| θ2 | 14.2 (9.6) | 14.2 (12.4–16.0) | ||
|
Vc0 (mL) = θ3 + θ4 × (WT/63) |
23.0 | |||
| θ3 | 0.95 (4.2) | 0.97 (0.004–1.07) | ||
| θ4 | 3440 (12.8) | 3280 (2120–3810) | ||
| Vt0(mL) | 2730 (32.1) | 38.0 | 3010 (2050–4320) | |
| kt (mL/min) | 181 (33.5) | – | 200 (136–460) | |
| σ | 0.00138 (12.5) | – | 0.0013 (0.0011–0.0015) | |
A log-normal distribution of inter-individual random variability was assumed. Residual random variability was modeled using an additive error model. Non-parametric bootstrap analysis was repeated 2000 times. RSE relative standard error = SE/estimate × 100 (%), MAP mean arterial pressure, WT actual body weight, kr elimination clearance (mL/min), Vc0 central volume of distribution at baseline (mL), Vt0 peripheral volume of distribution at baseline (mL), kt distributional clearance between central and peripheral compartment (mL/min)