Fig. 3.

JWX-A0108 enhances GABAergic synaptic transmission in brain slices. a Representative raw traces showing that co-application of JWX-A0108 and ACh significantly increased both the frequency and amplitude of sIPSCs compared with application of JWX-A0108 or ACh alone. The neurons were held at –70 mV. b Peak amplitude distributions of all IPSC events detected in a. c Normalized average IPSC peak amplitudes from all recordings. Co-application of JWX-A0108 and ACh increased IPSC amplitude in each individual neuron (n = 5). d Statistical analysis of average IPSC frequency from all neurons recorded (n = 6). Co-application of JWX-A0108 and ACh significantly increased the average frequency of the IPSCs. Data are expressed as the means ± SEM. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001. A0108 JWX-A0108