Fig. 8.

Effects of SB203580 on TMX-induced changes in hepatic gene expression. Mice were injected with the p38 inhibitor SB203580 (2 mg/kg) 1 h before the TMX injection. The mRNA levels of genes involved in oxidative stress (a), inflammation (b), and metabolism (c) were quantified using real-time RT-PCR 8 h after the TMX injection. Data are reported as the mean ± SEM, n = 4–6 mice per group. *P < 0.05, **P < 0.01 compared to the control, ^#P < 0.05, ^##P < 0.01 compared to TMX