Fig. 5.

Effects of CP-25 on AA rats. a The effects of CP-25 on the joint histopathology of AA rats. b A bar graph of the joints histological score is shown. ^#P < 0.05, ^##P < 0.01 vs. model group ($\overline{x}$ ± s, n = 6). c–d Effects of CP-25 on PGE2 and TNF-α in AA rats. e Effects of CP-25 on FLS proliferation in AA rats. *P < 0.05, **P < 0.01 vs. normal group; ^#P < 0.05, ^##P < 0.01 vs. model group ($\overline{x}$ ± s, n = 6–8). f Effects of CP-25 on FLS proliferation under stimulated PGE2 in vitro. **P < 0.01 vs. control; ^#P < 0.05, ^##P < 0.01 vs. PGE2 ($\overline{x}$ ± s, n = 3)