Table 1.
Groups | Dose (mg/kg) | d17 | d20 | d23 | d26 | d29 | d32 |
---|---|---|---|---|---|---|---|
Model | — | 10.22 ± 0.94 | 11.44 ± 0.97 | 11.67 ± 1.08 | 10.56 ± 0.97 | 9.67 ± 0.99 | 8.86 ± 1.02 |
CP-25 | 25 | 10.70 ± 1.25 | 10.90 ± 0.95 | 9.70 ± 0.68 | 8.70 ± 0.70 | 6.90 ± 0.57* | 4.90 ± 0.66** |
50 | 10.10 ± 1.33 | 10.10 ± 1.00 | 9.90 ± 1.12 | 7.40 ± 0.76 | 5.70 ± 0.67** | 4.10 ± 0.72** | |
100 | 10.60 ± 1.15 | 10.60 ± 0.91 | 8.30 ± 0.73 | 6.50 ± 0.73 | 5.10 ± 0.79** | 3.40 ± 0.69** | |
MTX | 0.5 | 10.70 ± 1.23 | 10.60 ± 1.08 | 7.90 ± 0.85 | 5.70 ± 0.77** | 3.60 ± 0.64** | 2.00 ± 0.45** |
*P < 0.05, **P < 0.01 vs. model group ( ± s, n = 8)