Figure 6.

Response of colonic migrating motor complexes (CMMCs) to a small conductance Ca²⁺-activated K⁺ channel (SK) agonist and antagonist in the colonic muscles of control (Con) and partial colon obstruction (PCO) mice. (A, B) The inhibitory effects of SK agonist, CyPPA (300 nM), on CMMCs in the proximal and distal colons in both control and PCO mice. (C, D) Summary of the area under the curve (AUC) data shows the normalized values to the control (before the application of CyPPA) (n = 5; *P < 0.05, CyPPA vs control; ^#P < 0.05, PCO vs control mice). (E, F) Response of CMMCs to apamin (300 nM) in the proximal and distal colons in both control and PCO mice. (G, H) Summary of the CMMCs to apamin in colonic muscles from control and PCO mice. The data were normalized to the control value (before the application of apamin) (n = 5; *P < 0.05, apamin vs control; ^#P < 0.05, PCO vs control mice).