Figure 7.

Contractile responses to the small conductance Ca²⁺-activated K⁺ channel (SK) agonist and antagonist in the colonic muscles of control (Con) and partial colon obstruction (PCO) mice. (A, B) The inhibitory effects of SK agonist, CyPPA (300 nM), on spontaneous contractions in the proximal and distal colons in both control and PCO mice. (C, D) Summary of the area under the curve (AUC) in control and PCO. The data were normalized to the control (before the application of CyPPA) (n = 5; *P < 0.05, CyPPA vs control; ^#P < 0.05, PCO vs control mice). (E, F) Response of colonic smooth muscle contractions to apamin (300 nM) in the proximal and distal colon in both control and PCO mice. (G, H) Summary of the contractile responses to apamin in the colonic muscles of control and PCO mice. The data were normalized to the control value (before the application of apamin) (n = 5; *P < 0.05, apamin vs control; ^#P < 0.05, PCO vs control mice).