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The library was generated with two cycles of acylation chemistry with amino acid (AA) and carboxylic acid (CA) monomers, respectively. Photochemical cleavage releases compound from the library bead as a primary amide. Physicochemical property analysis of photochemically cleaved compounds included hydrophobicity (cLogP), molar mass, hydrogen bond donors/acceptors, and polar surface area. Most compounds analyzed (1,738/1,766) are ‘drug-like’.
