Table 3. .
Odds Ratio for Unfavorable Outcome vs Treatment Completion Among EPTB Patients in Denmark, 2009–2014
| Characteristics at Time of EPTB Diagnosis | No. of Cases (%) | Factors Associated With Unfavorable Treatment Outcome, Univariate Logistic Regression | Factors Associated With Unfavorable Treatment Outcome, Multivariate Logistic Regression | |||
|---|---|---|---|---|---|---|
| Unfavorable Outcome | Treatment Completion | OR | 95% CI | OR | 95% CI | |
| Total | 20 (5.1) | 376 (94.9) | ||||
| Sex | ||||||
| Female | 4 (2.0) | 195 (98.0) | RF | |||
| Male | 16 (8.2) | 181 (91.8) | 4.33 | 1.42–13.23 | 5.18 | 1.79–15.04 |
| Age, y | ||||||
| 0–24 | 9 (12.3) | 64 (87.7) | 13.36 | 1.65–108.32 | 16.39 | 2.02–132.64 |
| 25–44 | 9 (4.4) | 195 (95.6) | 4.41 | 0.55–35.39 | 4.44 | 0.55–35.64 |
| 45–64 | 1 (1.0) | 95 (99.0) | RF | RF | ||
| ≥65 | 1 (4.4) | 22 (95.6) | 4.32 | 0.26–72.01 | 5.73 | 0.33–100.3 |
| Country of origin | ||||||
| Denmark | 3 (4.5) | 64 (95.5) | RF | |||
| Other | 17 (5.2) | 313 (94.8) | 1.17 | 0.33–4.11 | ||
| Predisposing factors | ||||||
| Alcohol | 2 (7.4) | 25 (92.6) | 1.87 | 0.40–8.73 | ||
| Tobacco | 7 (6.7) | 98 (93.3) | 1.98 | 0.72–5.49 | ||
| Cannabis | 2 (16.7) | 10 (83.3) | 4.83 | 0.96–24.4 | ||
| History of illegal drug use | 1 (12.5) | 7 (87.5) | 2.75 | 0.32–23.58 | ||
| Homelessness | 2 (20.0) | 8 (80.0) | 5.08 | 1.00–25.74 | ||
| History of incarceration | 0 (0.0) | 1 (100.0) | NA | |||
| Previously TB | 3 (8.6) | 32 (91.4) | 2.09 | 0.57–7.70 | ||
| History of mental illness | 2 (11.8) | 15 (88.2) | 2.67 | 0.57–12.58 | ||
| Charlson comorbidity score | ||||||
| 0 | 17 (5.8) | 275 (94.2) | ||||
| 1 | 0 (0.0) | 52 (100.0) | ||||
| ≥2 | 1 (2.4) | 40 (97.6) | 0.05–3.12 | 0.38 | ||
| Concomitant site | ||||||
| Any | 0 (0.0) | 14 (100.0) | NA | |||
| Superficial site of diseasec | 11 (4.8) | 218 (95.2) | RF | |||
| Deep site of disease | 9 (5.4) | 158 (94.6) | 1.12 | 0.45–2.78 | ||
| Diagnosis supported by: | ||||||
| Culture positive | 16 (5.0) | 307 (95.0) | 0.90 | 0.29–2.79 | ||
| Identification by contact tracing | 0 (0.0) | 13 (100.0) | NA | |||
| Clinical symptoms | ||||||
| Symptom duration >30 d | 11 (5.1) | 205 (94.9) | 1.18 | 0.42–3.27 | ||
| Time to diagnosis >30 d | 8 (4.2) | 181 (95.8) | 0.81 | 0.31–2.10 | ||
| Weight loss | 8 (5.6) | 136 (94.4) | 1.14 | 0.45–2.87 | ||
| Fever | 10 (7.1) | 131 (92.9) | 1.85 | 0.75–4.56 | ||
| Night sweet | 9 (7.3) | 114 (92.3) | 1.70 | 0.68–4.23 | ||
| Adherenceb | 3 (0.8) | 357 (99.2) | ||||
| Nonadherence | 16 (48.5) | 17 (51.5) | 112 | 29.7–422.38 | ||
Abbreviations: CI, confidence interval; EPTB, extrapulmonary tuberculosis; OR, odds ratio; RF, reference; TB, tuberculosis.
aA total of 395 cases were included in the multivariable analysis.
bNonadherence: if described in patient records and/or ≥2 episodes of nonattendance for clinical appointments.
cSuperficial site of disease: lymph node or/and skin.