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. 2019 Oct 10;14(10):e0223065. doi: 10.1371/journal.pone.0223065

Table 3. Biological processes as indicated by specific Gene Ontology Id’s most highly associated with variable mRNA within RNAgard® and PAXgene®RNA preservation methods.

GO Term
RNAgard® Gene Count FDR
GO:0006955~immune response 52 3.3E-06
GO:0006952~defense response 48 5.2E-06
GO:0009615~response to virus 18 4.0E-05
GO:0006954~inflammatory response 25 7.8E-02
GO:0009617~response to bacterium 18 1.2E-01
GO:0002831~regulation of response to biotic stimulus 7 3.2E-01
GO:0045087~innate immune response 14 4.4E-01
GO:0055066~di-, tri-valent inorganic cation homeostasis 19 5.5E-01
GO:0006916~anti-apoptosis 17 8.2E-01
GO:0030005~cellular di-, tri-valent inorganic cation homeostasis 18 8.4E-01
PAXgene®RNA
GO:0006955~immune response 92 1.2E-25
GO:0006952~defense response 71 2.3E-15
GO:0006954~inflammatory response 40 3.8E-08
GO:0009615~response to virus 23 4.6E-08
GO:0009611~response to wounding 50 1.2E-06
GO:0055066~di-, tri-valent inorganic cation homeostasis 28 1.8E-04
GO:0030005~cellular di-, tri-valent inorganic cation homeostasis 27 2.3E-04
GO:0009897~external side of plasma membrane 23 3.1E-04
GO:0048584~positive regulation of response to stimulus 27 5.0E-04
GO:0001775~cell activation 30 6.6E-04

Top 10 enrichment GO terms for genes within each platform with top 5% mean within individual variance using the DAVID annotation tool with gene count and FDR derived from the tool are listed here [11, 17].