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. 2019 Oct 10;14(10):e0223509. doi: 10.1371/journal.pone.0223509

Fig 2. Isoflurane selectively worsened Tau pathology in old 3xTg-AD mice and S100β release in neonatal NonTg mice.

Fig 2

Representative micrographs of AT180 positive cells in the CA1 region of the hippocampus of neonatal (A) and old (B) NonTg or 3xTg-AD mice following repeated sham or Iso exposures. Quantitative analysis of AT180 positive cells in the CA1 hippocampus of neonates (C) and old mice (D). Plasma level of S100β in neonates (E) and old mice (F). Statistical significance indicated with asterisks: ***p<0.001. N = 4 animals per group and counts are given as cells/mm2. Scale bar is 100μm.