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. 2019 Oct 10;14(10):e0223509. doi: 10.1371/journal.pone.0223509

Fig 4. Isoflurane altered distinct spatial learning paradigms in young and old 3xTg-AD and NonTg mice.

Fig 4

Latency to find the submerged platform in the reference learning of the MWM test during 5 consecutive days after repeated exposures of neonates (A) and old mice (B). Quantitative analysis of short-term (C) and long term (E) probe tests in neonates. Analysis of short-term (D) and long term (F) probe tests old mice. Time saved in short-term trial-dependent working memory paradigm in neonates (G) and old mice (H). Quantitative analysis of time saved during long-term trial-dependent working memory paradigm in neonates (I) and old mice (J). Motor function measured by the accelerated Rotarod paradigm was not altered by repeated Iso exposures in both neonatal (K) and old (L) mice. Statistical significance indicated with the following symbols: *p<0.05; **, ## p<0.01, ***, ###p<0.001. Statistical analyses denoted by # represent comparisons between sham and Iso treated 3xTg-AD mice and those denoted by * compared sham treated 3xTg and NonTg mice. N≥14 animals per group.