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. 2019 Oct 10;14(10):e0223509. doi: 10.1371/journal.pone.0223509

Fig 5. Repeated in vivo isoflurane exposures differentially altered basal synaptic transmission in NonTg and 3xTg-AD mice.

Fig 5

(A) Representative traces of CA1 field EPSPs recorded in response to SC stimulations on acute slices from sham- or Iso-treated neonatal NonTg (Top traces) and 3xTg-AD (Bottom traces) mice. (B) Representative traces of CA1 field EPSPs recorded as in panel A on acute slices from sham- or Iso-treated old NonTg (Top traces) and 3xTg-AD (Bottom traces) mice. Quantitative analysis of Input-output generated by plotting mean fEPSP slope to increasing current intensities in neonatal (C) and old mice (D). Statistical significance indicated with the following symbols: *,^p<0.05; **, ## p<0.01, ***, ###p<0.001. Statistical analyses denoted by # represent comparisons between sham- and Iso-treated NonTg mice and those denoted by * compared sham-treated 3xTg and NonTg mice. Statistical analyses denoted by ^ represent comparisons between sham- and Iso-treated old NonTg mice. N≥8 animals and ≥16 slices per group.