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. 2019 Oct 10;14(10):e0223509. doi: 10.1371/journal.pone.0223509

Fig 7. Repeated in vivo isoflurane exposures differentially altered LTP in NonTg and 3xTg-AD mice.

Fig 7

(A) Representative traces of CA1 field EPSPs recorded in response to SC stimulations before and after LTP induction on acute slices from sham- and Iso-treated neonatal NonTg (Top traces) and 3xTg-AD (Bottom traces) mice. (B) Representative traces of CA1 field EPSPs recorded as in panel A on acute slices from old NonTg (Top traces) and 3xTg-AD (Bottom traces) mice before and after LTP induction. (C) Normalized fEPSP slope before and after LTP induction (200Hz, 500ms) in sham- and iso-treated neonatal (C) and old (D) mice. (E) Quantitative analysis of the first 10 min of fEPSP slope following LTP induction on acute slices from sham and Iso-treated neonatal (E) and old (F) mice. Statistical significance indicated with the following symbols: *p<0.05; **p<0.01, ***p<0.001. N≥8 animals and ≥16 slices per group.