Table 2. Distribution of the LGALS9 alleles and genotypes in patients with RA and healthy individuals.
SNP genotype | RA | Control | p-value | RR | OR (95%IC) | ||
---|---|---|---|---|---|---|---|
rs4795835 | (N = 154) | % | (N = 195) | % | |||
CC | 103 | 66.88 | 109 | 55.89 | 0.063 | 0.83 | 0.65 (0.42–1.01) |
CT | 44 | 28.57 | 80 | 41.03 | 0.025 | 1.25 | 1.69 (1.08–2.64) |
TT | 7 | 4.54 | 6 | 3.07 | 0.415 | 0.76 | 0.59 (0.20–1.75) |
CT and TT | 51 | 33.11 | 86 | 44.10 | 0.063 | 1.20 | 1.52 (0.98–2.34) |
C- allele | 250 | 81.16 | 298 | 76.41 | 0.233 | 0.90 | 0.79 (0.54–1.13) |
T-allele | 58 | 18.83 | 92 | 23.58 | 0.233 | 1.10 | 1.26 (0.87–1.81) |
rs3763959 | (N = 105) | % | (N = 192) | ||||
AA | 7 | 6.67 | 29 | 15.10 | 0.040 | 1.29 | 2.49 (1.05–5.90) |
AG | 40 | 38.09 | 96 | 50 | 0.052 | 1.18 | 1.62 (1.00–2.63) |
GG | 58 | 55.23 | 67 | 34.89 | 0.0009 | 0.73 | 0.43 (0.26–0.70) |
AG and GG | 98 | 93.33 | 163 | 84.89 | 0.040 | 0.77 | 0.40 (0.16–0.95) |
A-allele | 54 | 25.71 | 154 | 40.10 | 0.0001 | 1.83 | 4.20 (2.90–6.09) |
G-allele | 156 | 74.28 | 230 | 59.89 | 0.0004 | 1.55 | 1.93 (1.33–2.80) |
rs4239242 | (N = 109) | % | (N = 192) | ||||
TT | 17 | 15.59 | 10 | 5.20 | 0.0032 | 0.54 | 0.28 (0.12–0.64) |
TC | 21 | 19.26 | 127 | 66.14 | 0.0001 | 2.03 | 7.99 (4.59–13.91) |
CC | 71 | 65.13 | 55 | 28.64 | 0.0001 | 0.55 | 0.22 (0.13–0.36) |
TC and CC | 92 | 84.40 | 182 | 94.79 | 0.0054 | 1.79 | 3.36 (1.48–7.64) |
T-allele | 55 | 25.22 | 147 | 38.28 | 0.0019 | 1.21 | 1.77 (1.23–2.55) |
C-allele | 163 | 74.77 | 237 | 61.71 | 0.0019 | 0.82 | 0.56 (0.39–0.80) |