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. 2019 Sep 30;15(9):e1008043. doi: 10.1371/journal.ppat.1008043

Fig 12. MCMV.env immunization confers long-lasting protection.

Fig 12

CB6F1 mice were immunized once or twice in a three-week interval, and infected with 5 000 SFFU FV 12 weeks after the first immunization. The Env-specific CD4+ T cell response (A) and binding antibody titers (B) were monitored over time. The neutralizing antibody response (C) and viral loads in plasma (D) were analysed ten days after FV infection, spleen weights (E) and spleen viral loads (F) were analysed three weeks after FV infection. Data were obtained in one experiment, each dot indicates one mouse, bars indicate mean (A, E) or median values (B-D, F), dotted lines indicate the limits of detection. Statistically significant differences compared to unvaccinated mice are indicated by * (P < 0.05, One Way ANOVA on Ranks, Dunn’s post test).