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. 2019 Sep 30;15(9):e1008043. doi: 10.1371/journal.ppat.1008043

Fig 13. Immunization in pre-existing MCMV-specific immunity.

Fig 13

CB6F1 mice were once immunized with MCMV.env, with or without one injection of non-transgene-encoding MCMV five weeks before. Six weeks after MCMV.env immunization, mice were infected with 5 000 SFFU FV. Viral loads in plasma were analysed ten days after FV infection (A), spleen weights (B) and spleen viral loads (C) were analysed three weeks after FV infection. The Env-specific CD4+ T cell response was analysed two weeks after MCMV.env immunization (D), F-MuLV neutralizing antibody titers were analysed ten days after FV infection (E). Data were obtained in one experiment, each dot indicates one mouse, bars indicate median (A, C, E) or mean values (B, D), dotted lines indicate the limits of detection. Statistically significant differences compared to unvaccinated mice are indicated by * (P < 0.05, One Way ANOVA on Ranks, Dunn’s post test).