Table 2.
Baseline and treatment characteristics according to type of malignancy
| Variable | Solid tumor (n = 658) | Hematologic malignancies (n=175) | P-value |
|---|---|---|---|
| Age (yr) | 65 (55-73) | 55 (42-65) | 0.005 |
| Male sex | 452 (70.2) | 102 (58.6) | 0.005 |
| ECOG performance statusa | 0.928 | ||
| 0-1 | 271 (44.2) | 78 (44.6) | |
| 2-4 | 342 (55.8) | 96 (54.9) | |
| Comorbidity (overlapped) | |||
| Hypertension | 191 (29.0) | 28 (16.0) | 0.001 |
| Diabetes | 121 (18.4) | 32 (18.3) | >0.999 |
| Congestive heart failure | 21 (3.2) | 9 (5.1) | 0.251 |
| Stroke | 28 (4.3) | 7 (4.0) | >0.999 |
| Chronic lung disease | 11 (1.7) | 3 (1.7) | >0.999 |
| Liver cirrhosis | 93 (14.1) | 4 (2.3) | <0.001 |
| Chronic renal failure | 32 (4.9) | 10 (5.7) | 0.703 |
| Severity of illness | |||
| SOFA | 8 (4-12) | 12 (8-15) | <0.001 |
| SAPS3 | 69 (60-79) | 71 (63-82) | <0.001 |
| Location before ICU admission | <0.001 | ||
| Emergency room | 323 (49.1) | 54 (30.9) | |
| General ward | 314 (47.7) | 115 (65.7) | |
| Other ICU | 15 (2.3) | 5 (2.9) | |
| Otherb | 6 (0.9) | 1 (0.6) | |
| Hospital days before ICU admission | 0 (0-2) | 0 (0-9) | 0.008 |
| Treatment history before ICU admission | |||
| Chemotherapy | 211 (32.1) | 100 (57.1) | <0.001 |
| Radiotherapy | 91 (13.8) | 14 (8.0) | 0.040 |
| Steroid | 13 (2.0) | 16 (9.1) | <0.001 |
| Immune suppression status | 48 (7.3) | 31 (17.7) | <0.001 |
| CPR before ICU admission | 26 (4.2) | 18 (10.5) | 0.001 |
| Unplanned ICU admission | 469 (71.3) | 151 (86.3) | <0.001 |
| Reason for ICU admission | |||
| Surveillance | 190 (28.9) | 38 (21.7) | 0.070 |
| Cardiovascular | 140 (21.3) | 61 (34.9) | <0.001 |
| Digestive | 45 (6.8) | 0 | 0.001 |
| Hematological | 3 (0.5) | 2 (1.1) | 0.283 |
| Hepatic failure | 29 (4.4) | 0 | 0.004 |
| Metabolic | 12 (1.8) | 0 | 0.081 |
| Neurological | 20 (3.0) | 9 (5.1) | 0.243 |
| Renal | 7 (1.1) | 2 (1.1) | 1.000 |
| Respiratory | 189 (28.7) | 62 (35.4) | 0.095 |
| Other | 20 (3.0) | 1 (0.6) | 0.098 |
| Acute infection at ICU admission | 298 (45.3) | 129 (73.7) | <0.001 |
| Severe sepsis/septic shock | 212 (32.2) | 100 (57.1) | <0.001 |
| Surgical status at ICU admission | <0.001 | ||
| No surgery | 566 (86.0) | 170 (97.1) | |
| Emergent surgery | 92 (14.0) | 5 (2.9) | |
| Initial laboratory variable | |||
| White blood cell (mm3) | 9,750 (5,320-15,460) | 3,640 (250-9,850) | <0.001 |
| Total bilirubin (mg/dl) | 0.9 (0.6-2.1) | 1.1 (0.7-2.3) | 0.297 |
| Creatinine (mg/dl) | 1.0 (0.7-1.6) | 1.1 (0.7-1.8) | 0.381 |
| Arterial pH | 7.39 (7.30-7.45) | 7.40 (7.30-7.46) | 0.159 |
| Lactic acid (mmol/l) | 2.90 (1.70-5.40) | 2.65 (1.50-5.23) | 0.468 |
| C-reactive protein (mg/dl) | 12.3 (4.3-21.3) | 14.5 (6.3-24.3) | 0.082 |
| Procalcitonin (ng/ml) | 3.64 (0.65-22.87) | 8.12 (0.19-27.12) | 0.988 |
| NT-proBNP (pg/ml) | 681 (161-3039) | 965 (315-6070) | 0.019 |
| Treatment | |||
| Total infused fluids within 24 hr (ml) | 3,339 (2,275-4,775) | 4,039 (3,001-5,246) | <0.001 |
| Inotrope/vasopressor within 24 hr | 293 (44.7) | 96 (54.8) | 0.017 |
| Norepinephrine | 251 (38.4) | 84 (48.8) | 0.012 |
| Vasopressin | 53 (8.3) | 29 (17.2) | 0.001 |
| Dopamine | 64 (10.0) | 19 (11.3) | 0.631 |
| Dobutamine | 51 (7.9) | 20 (11.8) | 0.108 |
| Epinephrine | 5 (0.8) | 2 (1.2) | 0.643 |
| Mechanical ventilation | 219 (33.3) | 82 (46.9) | 0.001 |
| Continuous renal replacement therapy | 60 (9.5) | 30 (17.6) | 0.004 |
Values are presented as median (interquartile range) or number (%).
ECOG: Eastern Cooperative Oncology Group; SOFA: Sequential Organ Failure Assessment; SAPS3: Simplified Acute Physiology Score 3; ICU: intensive care unit; CPR: cardiopulmonary resuscitation; NT-proBNP: N-terminal prohormone of brain natriuretic peptide.
a
Data were available for 787 patients;
b
Includes patients with spinal stenosis, trauma, urinary incontinence, and mood depression disorder.