Table 2.
Unadjusted Outcomes Summary
| Outcome Variable | Preswitch (TDF) |
Postswitch (TAF) | Change (Post–Pre) | P Value |
|---|---|---|---|---|
| Weight (lbs), median (IQR) | 185.4 (55.8) | 190.5 (60.5) | 3.0 (9.2) | <.01 |
| BMI (kg/m2), median (IQR) | 28.0 (10.8) | 28.2 (10.0) | 0.5 (1.4) | <.01 |
| Total cholesterol, median (IQR) | 173.8 (44.0) | 195.0 (42.0) | 12.5 (32.3) | <.01 |
| LDL cholesterol, median (IQR) | 98.6 (40.2) | 112.1 (46.6) | 8.2 (21.0) | <.01 |
| HDL cholesterol, median (IQR) | 51.0 (19.0) | 55.8 (24.0) | 3.0 (12.0) | <.01 |
| Total to HDL cholesterol ratio, median (IQR) | 3.5 (1.6) | 3.5 (1.7) | 0.1 (0.6) | .25 |
| Triglyceride levels, median (IQR) | 103.5 (68.0) | 109.5 (93.0) | 4.0 (64.0) | .28 |
| Atherosclerotic CVD risk score, median (IQR) | 6.9 (8.1) | 8.1 (10.9) | 0.4 (1.9) | <.01 |
| Creatinine clearance, median (IQR) | 104.0 (38.0) | 102.5 (42.0) | −1.0 (17.0) | .82 |
Abbreviations: BMI, body mass index; CVD, cardiovascular disease; HDL, high-density lipoprotein; IQR, interquartile range; LDL, low-density lipoprotein; TAF, tenofovir alafenamide; TDF, tenofovir disoproxil fumarate.