Table 1.
Baseline characteristics of AKI patients who received CRRT
| Variable | Survivor (n = 17) | Non-survivor (n = 14) | P-value |
|---|---|---|---|
| Age (yr) | 67 (42–78) | 69 (53–79) | 0.653 |
| Male | 10 (58.8) | 8 (57.1) | 0.925 |
| Comorbidity | |||
| Hypertension | 7 (41.2) | 4 (28.6) | 0.707 |
| Diabetes | 6 (35.3) | 7 (50.0) | 0.409 |
| Liver disease | 3 (17.6) | 4 (28.6) | 0.671 |
| Heart failure | 3 (17.6) | 2 (14.3) | 1.000 |
| Reason for admission | 0.560 | ||
| Infection | 9 (52.9) | 9 (64.3) | |
| Cardiovascular | 2 (11.8) | 3 (21.4) | |
| Gastrointestinal | 4 (23.5) | 1 (7.1) | |
| Others | 2 (11.8) | 1 (7.1) | |
| Duration from ICU to CRRT (d) | 1 (0–3) | 1 (1–3) | 0.246 |
| Cause of AKIa | 0.603 | ||
| Septic | 9 (52.9) | 9 (64.3) | |
| Cardiorenal | 1 (5.9) | 2 (14.3) | |
| Ischemic | 4 (23.5) | 2 (14.3) | |
| Hepatorenal | 2 (11.8) | 0 | |
| Others | 1 (5.9) | 1 (7.1) | |
| CRRT indication | |||
| Pulmonary edema | 8 (47.1) | 8 (57.1) | 0.576 |
| Hyperkalemia | 3 (17.6) | 4 (28.6) | 0.671 |
| Metabolic acidosis | 7 (41.2) | 8 (57.1) | 0.376 |
| Uremic symptom | 6 (35.3) | 5 (35.7) | 0.981 |
| SOFA score | |||
| Respiratory | 3 (2–3) | 3 (3–3) | 0.518 |
| Cardiovascular | 3 (0–4) | 3 (1–4) | 0.421 |
| Nervous | 2 (1–4) | 4 (3–4) | 0.026 |
| Liver | 0 (0–1) | 0 (0–2) | 0.493 |
| Coagulation | 1 (0–2) | 1 (0–2) | 0.518 |
| Renal | 3 (2–4) | 2 (1–3) | 0.186 |
| Total | 11 (8–13) | 14 (11–15) | 0.040 |
| Oliguria (<400 ml/d) | 9 (52.9) | 10 (71.4) | 0.461 |
| Daily fluid balance (L/d) | 1.3 (0.4–2.9) | 2.3 (1.8–3.7) | 0.048 |
| Cumulative fluid balance (L) | 2.2 (0.5–5.1) | 5.9 (4.3–7.5) | 0.008 |
| Hematocrit (%) | 31.1 (24.1–41.3) | 28.8 (26.4–33.6) | 0.769 |
| Albumin (g/dl) | 2.9 (2.6–3.5) | 2.3 (2.1–2.8) | 0.007 |
| CRP (mg/L) | 129.0 (64.6–151.4) | 129.1 (67.0–216.0) | 0.681 |
| Lactate (mmol/L) | 1.8 (1.0–5.2) | 3.0 (2.1–8.4) | 0.053 |
| BNP (pg/ml) | 122.5 (75.5–830.7) | 570.4 (130.3–807.6) | 0.201 |
| Total CO2 (mmol/L) | 15.5 (12.1–20.5) | 13.9 (10.7–17.0) | 0.316 |
| ECW/TBW | 0.40 (0.40–0.42) | 0.42 (0.41–0.44) | 0.044 |
Values are presented as median (interquartile range) or number (%).
AKI: acute kidney injury; CRRT: continuous renal replacement therapy; ICU: intensive care unit; SOFA: Sequential Organ Failure Assessment; CRP: C-reactive protein; BNP: brain natriuretic protein; CO2: carbon dioxide; ECW/TBW: the ratio of extracellular water to total body water.
a
AKI refers to an abrupt loss of kidney function requiring CRRT that develops within 7 days.