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. 2019 Jan 29;6(1):78–89. doi: 10.1007/s40472-019-0230-4

Table 1.

Representative DAMPs and receptors

Molecules Receptors
Nucleus:
 HMGB1 TLR2, TLR4, TLR9, CD24, RAGE
 Histone TLR2, TLR4, NLRP3
 DNA TLR9, AIM2
Cytosol:
 S100 protein TLR2, TLR4, RAGE
 Heat shock protein TLR2, TLR4, CD14, CD91, CD34
 Uric acid NLRP3
Mitochondria:
 ATP P2X7, NLRP, P2Y2
 Formyl peptide FPR1, FPR2
 mtDNA TLR9
Extracellular matrix
 Hyaluronic acid TLR2, TLR4, CD44