Table 2.

Parameter sets used in the model

Set no.	mS/cm2						×104	ms		mV
	gM8	gl	gsd	gsr	gd	gr	pCa	τCa	τδV	δVmin	δVmax
1	2.3	0.27	0.29	0.20	3.7	5.0	1.8	23400	1300	−160	215
2	1.4	0.24	0.28	0.22	3.5	4.9	2.5	27500	1250	−220	170
3	0.9	0.21	0.35	0.31	3.0	4.4	1.3	24000	3100	−230	250
4	0.4	0.17	0.21	0.28	4.0	4.9	4.7	14000	8200	−250	110
5	0.5	0.16	0.20	0.28	3.9	4.7	5.2	14000	9600	−225	150
6	3.5	0.24	0.30	0.25	4.0	5.0	3.5	20000	1300	−230	185
7	4.3	0.22	0.25	0.21	3.9	5.0	3.2	40000	3500	−150	170
8	1.3	0.21	0.28	0.26	3.8	4.7	3.6	26000	4000	−250	150
9	3.5	0.27	0.32	0.20	2.8	4.9	3.4	23500	5000	−190	235
10	3.3	0.26	0.33	0.21	3.0	4.7	3.3	39000	9200	−220	250
11	3.2	0.18	0.21	0.23	2.5	3.4	4.6	24500	7000	−230	240
12	2.0	0.19	0.21	0.22	2.7	3.0	4.7	19000	15000	−230	250
13	2.7	0.20	0.21	0.20	2.4	2.3	5.5	24000	8300	−250	230
14	2.0	0.27	0.33	0.21	2.7	4.6	1.9	24000	5100	−130	240
15	1.3	0.28	0.34	0.20	3.3	4.7	1.4	38000	4100	−140	240
16	2.0	0.29	0.34	0.20	3.0	4.2	4.8	21500	1400	−210	170
17	1.4	0.28	0.34	0.20	3.1	5.0	3.8	18000	5400	−150	190
18	2.6	0.27	0.33	0.21	2.8	3.7	5.4	16000	9100	−140	170
19	1.6	0.23	0.25	0.20	4.0	5.0	5.8	19000	6250	−220	170
20	3.0	0.23	0.25	0.20	4.0	5.0	5.8	19000	6200	−250	250

g_M8, g_l, g_sd, g_sr, g_d, and g_r are the maximum conductance densities of the respective ion currents (representative of the ion channel expression level). p_Ca is a parameter that control how much the TRPM8 current contributes to an increase in [Ca²⁺]_i and channel desensitization. τ_Ca and τδ_V are the time constants for Ca²⁺ removal and for the desensitization process, respectively. δV_min and δV_max are the maximum values for TRPM8 V_1/2 displacement due to Ca²⁺-dependent desensitization (see Olivares and Orio, 2015; Olivares et al., 2015).