Caiazzo 2011.
| Methods | Multicentre parallel RCT with 4 arms, of 3 months' duration. No drop‐outs | |
| Participants | Adult treated in 2 private Italian dental practices. Participants were excluded if they had: a history of systemic diseases contraindicating surgical treatment, long‐term nonsteroidal anti‐inflammatory drug therapy, medically necessary antibiotic therapy, a history of antibiotic therapy 6 months prior to the study, a history of allergic reactions to penicillins or related drugs, or were pregnant. 25 participants included in each group and results given for 100 | |
| Interventions | 4 interventions compared: 2 g of amoxicillin given 1 h preoperatively; 2 g amoxicillin given 1 h preoperatively + 1 g twice a day for 7 days; 1 g of amoxicillin given immediately after implantation twice a day for 7 days; and no antibiotic. All participants had at least 1 session of oral hygiene instruction and professionally‐delivered debridement 1 week prior to implant placement. All participants rinsed with chlorhexidine digluconate 0.2% for 1 minute just prior to surgery and postoperatively twice a day for 15 days. Clinicians placed implants according to their routine procedures. Postoperative complications were assessed at 1, 2, 4 and 8 weeks, and implant success at 3 months. Used Biomet 3i Osseotite implants with external connection | |
| Outcomes | Implant failures, postoperative complications, adverse events. Postoperative complications assessed 1, 2, 4 and 8 weeks after placement, and implant stability at 3 months | |
| Notes | No external funding was received | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Low risk | Quoted from the article: "The patients were randomly allocated ‐ using a computer‐generated randomisation list ‐ to 4 different groups: . . . " The authors also informed us that they used the Random Allocation Software to prepare the randomisation schedule |
| Allocation concealment (selection bias) | High risk | No information provided in the article The authors kindly informed us that no allocation concealment procedures were implemented |
| Blinding (performance bias and detection bias) All outcomes | High risk | No information provided in the article The authors kindly informed us that the operators recorded the outcome measures, so they were not blinded |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | No missing data or excluded patients |
| Selective reporting (reporting bias) | Low risk | All outcome measures reported |
| Other bias | Low risk | No other bias identified |