2.
| Emdogain compared with GTR for periodontal tissue regeneration in intrabony defects | ||||||
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Patient or population:patients with intrabony defects Settings: practice Intervention: Emdogain Comparison: GTR | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| GTR4 | Emdogain | |||||
| Tooth loss | See comment | See comment | 237 [5] | See comment | too few teeth lost to undertake analysis | |
| PAL1 mm gain from baseline 1 year |
The mean PAL gain ranged across GTR groups from 2.5 to 4.9 | The mean PAL gain in the intervention groups was 0.2 lower (‐0.20 to 0.55 lower) | 304 [6] | ++OO low | ||
| PPD2 mm reduction from baseline 1 year |
The mean PPD reduction ranged across GTR groups from 3.3 to 6.5 | The mean PPD reduction in the intervention groups was 0.4 lower (‐0.2 to 1.1 lower) | 304 [6] | ++OO low | ||
| Aesthetics | See comment | See comment | 0 [0] |
See comment | No studies reported this | |
| REC3 mm change from baseline 1 year |
The mean REC change ranged across GTR groups from ‐1.8 to 1.0 | The mean REC change in the intervention groups was 0.4 higher (0.2 to 0.7 higher)(less recession) | 206 [5] | ++OO low | ||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; GRADE: GRADE Working Group grades of evidence (see explanations) | ||||||
GRADE Working Group grades of evidence High quality (++++): Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality (+++O): Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality (++OO): Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality (+OOO): We are very uncertain about the estimate.
1 probing attachment level
2 probing pocket depth
3 gingival recession
4 Guided Tissue Regeneration