Table 2.
Univariate analysis with PEDF difference between pass2 and pass1 (pass2 - pass1). For each clinical characteristic PEDF difference is modeled as the dependent variable with the clinical characteristic being measured either at VADT baseline or at the time of the first PEDF measurement.
| Clinical Characteristic | N | Unadjusted Regression Coefficient Estimates* |
P-value | Adjusted* Regression Coefficient Estimates |
P-value |
|---|---|---|---|---|---|
| At VADT Baseline | |||||
| Age (years) | 743 | −0.02 | 0.28 | −0.04 | 0.04 |
| Diabetes Duration (years) | 735 | 0.04 | 0.09 | 0.03 | 0.19 |
| Non-Hispanic White (%) | 743 | −0.21 | 0.52 | −0.42 | 0.18 |
| Intensive Treatment (%) | 743 | −0.24 | 0.45 | −0.36 | 0.23 |
| Prior Vascular Event (%) | 743 | 0.18 | 0.57 | 0.31 | 0.32 |
| Current Smoker (%) | 743 | −0.06 | 0.90 | −0.07 | 0.86 |
| Hypertension† (%) | 740 | 0.27 | 0.45 | 0.40 | 0.23 |
| Exercise (%) | 742 | −0.21 | 0.50 | −0.39 | 0.19 |
| Adherent to Diet (%) | 742 | −0.29 | 0.37 | −0.57 | 0.06 |
| At time of first PEDF Measure | |||||
| Aspirin (%) | 741 | 0.11 | 0.86 | −0.02 | 0.97 |
| Statin (%) | 741 | 0.20 | 0.59 | −0.39 | 0.29 |
| ACE (%) | 741 | 0.01 | 0.97 | −0.04 | 0.90 |
| ARB (%) | 741 | 0.06 | 0.88 | 0.66 | 0.16 |
| eGFR | 741 | −0.01 | 0.37 | −0.02 | <0.01 |
| Serum Creatinine | 741 | 0.91 | 0.11 | 2.33 | <0.01 |
| Hemoglobin A1c (%) | 741 | −0.07 | 0.52 | 0.01 | 0.90 |
| Ln Urine ACR (mg/g) | 741 | 0.19 | 0.04 | 0.39 | <0.01 |
| Body Mass Index (kg/m2) | 741 | 0.06 | 0.05 | 0.13 | <0.01 |
| Systolic BP (mmHg) | 741 | 0.01 | 0.21 | 0.01 | 0.15 |
| Diastolic BP (mmHg) | 741 | 0.004 | 0.78 | 0.002 | 0.88 |
| HDL–Cholesterol (mg/dl) | 741 | 0.03 | 0.09 | −0.02 | 0.28 |
| LDL–Cholesterol (mg/dl) | 740 | 0.01 | 0.26 | 0.004 | 0.46 |
| Ln Triglycerides (mg/dl) | 741 | 0.44 | 0.12 | 1.37 | <0.01 |
*
Adjusted for PEDF at pass1
†
History of hypertension