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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: Nat Metab. 2019 Apr 22;1(5):546–559. doi: 10.1038/s42255-019-0055-6

Figure 2. 4-MU treatment improves insulin sensitivity.

Figure 2

(a) Intraperitoneal glucose tolerance test performed after 13 weeks of feeding diabetogenic diet (DD) supplemented with or without 4-MU in male C57BL/6J mice; n = 7,8. Absolute values of blood glucose concentration (left) at 0, 5, 15, 30, 60, and 120 minutes, and respective area under the curve (AUC; right) are shown. (b) Insulin tolerance test performed after 14 weeks of feeding; n = 8,8 biologically independent samples. Absolute values of blood glucose concentration (left) at 0, 15, 30, 60, and 120 minutes, and respective area under the curve (AUC; right) are shown. (c) Fasting plasma insulin concentrations measured after 22 weeks of feeding; n = 7,6 biologically independent samples. Data are presented as means ± s.e.m.. (a, b left) Two-way ANOVA with post hoc Sidak`s multiple comparison test, P: DD 4-MU versus DD; (a, b right, c) two-tailed unpaired Student’s t-test.