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. Author manuscript; available in PMC: 2020 Oct 10.
Published in final edited form as: J Med Chem. 2019 May 7;62(19):8695–8710. doi: 10.1021/acs.jmedchem.8b01906

Figure 6.

Figure 6

PK/PD relationship of GX-585 (13) and GX-201 (14) in mouse models of thermal, mechanical, chemical and inflammatory pain. “+” indicates effective in PD model. “–” indicates not effective. Ave. Cp = average total plasma concentration.30