Extended Data Fig. 5. Example region of association in standing height GWAS.

GWAS association statistics (P values) for standing height focusing on a ~3-Mb region of chromosome 2 that did not reach genome-wide significance in the GIANT (2014) meta-analysis, but did in UK Biobank (linear mixed model; see Methods). The P values shown are not adjusted for multiple testing. Markers genotyped in the UK Biobank are shown as diamonds, and imputed markers as circles. The two markers with the smallest P value for each of the genotyped data and imputed data are enlarged and highlighted with black outlines, and other UK Biobank markers are coloured according to their correlation (r²) with one of these two. That is, genotyped markers with the leading genotyped marker (rs17713396), and imputed markers with the leading imputed marker (rs12714401). Markers with r² values of less than 0.1 are shown as black or green.