Table 4.
New onset dementia | Hospitalization for cardiac event | All‐cause mortality | Composite secondary endpoint | |||||
---|---|---|---|---|---|---|---|---|
Adjusted HR | P value | Adjusted HR | P value | Adjusted HR | P value | Adjusted HR | P value | |
Age (years old) | 1.12 (1.01‐1.24) | .03 | 1.70 (0.94‐3.12) | .08 | 1.21 (1.12‐1.32) | <.01 | 1.04 (1.00‐1.08) | .06 |
BW (kg) | 0.99 (0.95‐1.03) | .59 | 1.00 (0.98‐1.02) | .65 | ||||
AF type (persistent) | 0.59 (0.27‐1.33) | .21 | 1.11 (0.69‐1.80) | .66 | ||||
Serum creatinine | 1.25 (1.02‐1.53) | .03 | 1.20 (1.00‐1.43) | .05 | ||||
AF ablation history | 0.44 (0.20‐0.99) | .04 | 0.25 (0.03‐1.94) | .18 | 0.50 (0.25‐0.99) | .04 | ||
Valvular disease | 1.70 (0.35‐8.30) | .52 | 2.27 (1.22‐4.22) | <.01 | 1.68 (0.70‐4.03) | .24 | 1.68 (1.01‐2.78) | .05 |
Ischemic heart disease | 1.73 (0.71‐4.22) | .23 | 0.82 (0.22‐3.10) | .77 | 1.23 (0.57‐2.66) | .59 | ||
Cardiomyopathy | 1.49 (0.14‐15.48) | .74 | ||||||
EF < 35% | 2.04 (0.27‐15.14) | .90 | 5.71 (1.68‐19.42) | <.01 | 2.65 (0.63‐11.20) | .18 | ||
Heart failure | 4.92 (0.86‐28.19) | .07 | 2.12 (1.12‐4.00) | .02 | 2.37 (0.94‐5.96) | .07 | 2.24 (1.35‐3.73) | <.01 |
Age > 75 years | 0.51 (0.12‐2.21) | .37 | 1.15 (0.58‐2.29) | .70 | ||||
Diabetes mellitus | 3.51 (1.17‐10.54) | .03 | 1.34 (0.48‐3.71) | .57 | 0.88 (0.48‐1.62) | .70 | ||
Stroke/TIA | 1.73 (0.55‐5.43) | .34 | ||||||
Vascular disease | 3.41 (0.92‐12.65) | .07 | 1.98 (0.79‐4.97) | .14 | 3.18 (0.92‐10.94) | .07 | 2.31(1.13‐4.75) | .02 |
Antiplatelet drugs | 1.44 (0.56‐3.67) | .45 | 1.22 (0.38‐3.95) | .74 | 1.22 (0.59‐2.50) | .59 |
Abbreviations: AF; atrial fibrillation; BW; body weight; EF; ejection fraction; SE; systemic embolism; TIA; transient ischemic attack.