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. 2019 Aug 16;35(5):697–708. doi: 10.1002/joa3.12226

Table 4.

Cox regression analysis of the secondary endpoint and clinical characteristics

  New onset dementia Hospitalization for cardiac event All‐cause mortality Composite secondary endpoint
Adjusted HR P value Adjusted HR P value Adjusted HR P value Adjusted HR P value
Age (years old) 1.12 (1.01‐1.24) .03 1.70 (0.94‐3.12) .08 1.21 (1.12‐1.32) <.01 1.04 (1.00‐1.08) .06
BW (kg)         0.99 (0.95‐1.03) .59 1.00 (0.98‐1.02) .65
AF type (persistent)         0.59 (0.27‐1.33) .21 1.11 (0.69‐1.80) .66
Serum creatinine     1.25 (1.02‐1.53) .03     1.20 (1.00‐1.43) .05
AF ablation history     0.44 (0.20‐0.99) .04 0.25 (0.03‐1.94) .18 0.50 (0.25‐0.99) .04
Valvular disease 1.70 (0.35‐8.30) .52 2.27 (1.22‐4.22) <.01 1.68 (0.70‐4.03) .24 1.68 (1.01‐2.78) .05
Ischemic heart disease     1.73 (0.71‐4.22) .23 0.82 (0.22‐3.10) .77 1.23 (0.57‐2.66) .59
Cardiomyopathy         1.49 (0.14‐15.48) .74    
EF < 35%     2.04 (0.27‐15.14) .90 5.71 (1.68‐19.42) <.01 2.65 (0.63‐11.20) .18
Heart failure 4.92 (0.86‐28.19) .07 2.12 (1.12‐4.00) .02 2.37 (0.94‐5.96) .07 2.24 (1.35‐3.73) <.01
Age > 75 years         0.51 (0.12‐2.21) .37 1.15 (0.58‐2.29) .70
Diabetes mellitus 3.51 (1.17‐10.54) .03     1.34 (0.48‐3.71) .57 0.88 (0.48‐1.62) .70
Stroke/TIA         1.73 (0.55‐5.43) .34    
Vascular disease 3.41 (0.92‐12.65) .07 1.98 (0.79‐4.97) .14 3.18 (0.92‐10.94) .07 2.31(1.13‐4.75) .02
Antiplatelet drugs     1.44 (0.56‐3.67) .45 1.22 (0.38‐3.95) .74 1.22 (0.59‐2.50) .59

Abbreviations: AF; atrial fibrillation; BW; body weight; EF; ejection fraction; SE; systemic embolism; TIA; transient ischemic attack.