Table 4.

Cox regression analysis of the secondary endpoint and clinical characteristics

	New onset dementia		Hospitalization for cardiac event		All‐cause mortality		Composite secondary endpoint
	Adjusted HR	P value	Adjusted HR	P value	Adjusted HR	P value	Adjusted HR	P value
Age (years old)	1.12 (1.01‐1.24)	.03	1.70 (0.94‐3.12)	.08	1.21 (1.12‐1.32)	<.01	1.04 (1.00‐1.08)	.06
BW (kg)					0.99 (0.95‐1.03)	.59	1.00 (0.98‐1.02)	.65
AF type (persistent)					0.59 (0.27‐1.33)	.21	1.11 (0.69‐1.80)	.66
Serum creatinine			1.25 (1.02‐1.53)	.03			1.20 (1.00‐1.43)	.05
AF ablation history			0.44 (0.20‐0.99)	.04	0.25 (0.03‐1.94)	.18	0.50 (0.25‐0.99)	.04
Valvular disease	1.70 (0.35‐8.30)	.52	2.27 (1.22‐4.22)	<.01	1.68 (0.70‐4.03)	.24	1.68 (1.01‐2.78)	.05
Ischemic heart disease			1.73 (0.71‐4.22)	.23	0.82 (0.22‐3.10)	.77	1.23 (0.57‐2.66)	.59
Cardiomyopathy					1.49 (0.14‐15.48)	.74
EF < 35%			2.04 (0.27‐15.14)	.90	5.71 (1.68‐19.42)	<.01	2.65 (0.63‐11.20)	.18
Heart failure	4.92 (0.86‐28.19)	.07	2.12 (1.12‐4.00)	.02	2.37 (0.94‐5.96)	.07	2.24 (1.35‐3.73)	<.01
Age > 75 years					0.51 (0.12‐2.21)	.37	1.15 (0.58‐2.29)	.70
Diabetes mellitus	3.51 (1.17‐10.54)	.03			1.34 (0.48‐3.71)	.57	0.88 (0.48‐1.62)	.70
Stroke/TIA					1.73 (0.55‐5.43)	.34
Vascular disease	3.41 (0.92‐12.65)	.07	1.98 (0.79‐4.97)	.14	3.18 (0.92‐10.94)	.07	2.31(1.13‐4.75)	.02
Antiplatelet drugs			1.44 (0.56‐3.67)	.45	1.22 (0.38‐3.95)	.74	1.22 (0.59‐2.50)	.59

Abbreviations: AF; atrial fibrillation; BW; body weight; EF; ejection fraction; SE; systemic embolism; TIA; transient ischemic attack.