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. 2019 Oct 10;10(10):776. doi: 10.1038/s41419-019-2006-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a CD68⁺ cell numbers in normal mucosa and tumoral stroma of 79 cases of primary colon cancer. b Representative images of RGC-32 expression in peritumoral and tumor tissue in colon cancer (small: 100×; large 400×). c The percentage of high-RGC-32 cases in normal and tumor samples. d A typical CD68 and RGC-32 expression in two consecutive sections (small: 100×; large 400×). e The percentage of samples with RGC-32⁺CD68⁺ macrophages and RGC-32⁻CD68⁺ macrophages in normal and tumor specimens. f The percentage of cases with RGC-32⁺CD68⁺ macrophages and RGC-32⁻CD68⁺ macrophages in the early stage and late stage group