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. 2019 Oct 10;10(10):776. doi: 10.1038/s41419-019-2006-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a COX-2 expression in HCT-116 cells was affected by the CMs of shRGC-32 and shRNA-transfected THP-1 macrophages or GV492-RGC-32 and GV492-transfected THP-1 macrophages. b, c HCT-116 cells were pretreated with celecoxib (10 μM), and then were stimulated by CMs from GV492-RGC-32 and GV492-transfected macrophages, respectively. The cell colony formation and migration of HCT-116 cells were determined. d TGF-β1 NAb inhibited COX-2 expression of HCT-116 cells stimulated by the CMs of THP-1 macrophage. All data are shown as the mean ± SD. *p < 0.05, **p < 0.01