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. 2019 Oct 10;9:14581. doi: 10.1038/s41598-019-51056-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genome-wide expression analysis reveals unique signatures in cells with reduced expression of CK2α. (a) KEGG pathway analysis of H9c2-CK2α-44 cells left untreated or incubated with 1 µg/ml doxycycline for three days (upper bar-plot) and (b) of the parental cell line (i.e. H9c-2 cell line) transfected with scramble siRNA (scr-siRNA) or siRNA directed against CK2α (CK2α-siRNA, lower bar-plot) for three days following global transcription analysis by RNA-Seq. Bar-plots show enriched pathways with respect to the number of significantly down-regulated genes within each pathway relative to controls. Panels to the right display volcano plots showing log₁₀ of P-values against log₂ Fold-change of gene expression. Dots above dashed line refer to genes with an adjusted P-value (padj) ≤0.1.