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HypaCas9 can introduce allele-specific mutation by SNP discrimination. a Design of two C57BL/6N allele-targeting gRNAs in Cdx2 exon 3. SNP rs32379528 exists in the PAM of gRNA1 and the protospacer of gRNA2. b Schematic for introducing allele-specific mutation in the B6D2F1 zygote by SNP discrimination. The results are shown in Table 1
