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. 2019 Oct 10;9:14614. doi: 10.1038/s41598-019-51175-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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p38α ablation in mature hepatocyte is hepatoprotective against CCl₄-induced liver injury. (a) Schematic representation of experimental procedure for CCl₄ injection in control mice (CTR) and p38α^ΔH mice. (b) Representative haematoxylin and eosin (H&E) staining of liver tissue sections from CTR and p38α^ΔH mice at different time points after CCl₄ injection. (c) Quantification of necrotic area from H&E stained CTR and p38α^ΔH liver sections at indicated time points after CCl₄ injection. Data represent the mean ± SEM (n ≥ 7 per group); *p < 0.05, ***p < 0.001 (two-tailed t-test). Average alanine aminotransferase (ALT) levels in CTR and p38α^ΔH sera samples at indicated time points after CCl₄ injection. Data represent the mean ± SEM (n ≥ 6 per group); *p < 0.05 (two-tailed t-test). (e,f) Relative mRNA level of Collagen 1α1 (e) and Collagen 3α1 (f) measured by quantitative PCR in CTR and p38α^ΔH liver samples at indicated time points after CCl₄ injection. Gene expression levels were normalized to the abundance of 18s mRNA for each sample. Data represent the mean ± SEM (n ≥ 6 per group); *p < 0.05, **p < 0.01 (two-tailed t-test).