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. 2019 Oct 10;9:14490. doi: 10.1038/s41598-019-50899-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transplantation of mBax_499 mRNA treated hESC-CMs and testing for teratoma formation. Cardiac differentiated hESCs were treated with mBax_499 mRNA at day 15 for 24 h. (a) FACS analysis of cells stained with OCT3/4 for pluripotency (n = 3). p value was generated using one-way ANOVA with Tukey’s post-hoc test for multiple comparisons. *p < 0.05. (b–d) Teratoma formation was evaluated by injecting 10⁶ cells in matrigel subcutaneously into SCID/NOD mice. (b) selected images of MRI body scan of subject without teratoma (left) and subject with teratoma (right - red arrow). (c) Bar graph representing the summarized results. (d) Selected images of Hematoxylin & Eosin staining of embedded tissues, dissected from mice that developed teratomas, presenting structures from all three germ layers. MES – mesoderm, ECT – ectoderm, END – endoderm. Scale bar: 100 µm.