Table 1.
Results of hearing threshold measurements with auditory brainstem response (ABR) tests in wild-type (WT) and PACAP-deficient (KO) mice with different stimuli at 1.5, 4 and 8 months of age. ns = non-significant.
| Age | Stimulus | WT (Mean ± SEM) | KO (Mean ± SEM) | p value |
|---|---|---|---|---|
| 1.5 months | click | 25 ± 2.33 dB | 54.62 ± 3.15 dB | p < 0.0001 |
| 1.5 months | 4.1 kHz | 33.1 ± 2.33 dB | 66.92 ± 3.5 dB | p < 0.0001 |
| 1.5 months | 8.2 kHz | 34.48 ± 3.04 dB | 65 ± 2.9 dB | p < 0.0001 |
| 4 months | click | 42.78 ± 3.31 dB | 74.67 ± 2.74 dB | p < 0.0001 |
| 4 months | 4.1 kHz | 43.89 ± 4.13 dB | 81.33 ± 4.24 dB | p < 0.0001 |
| 4 months | 8.2 kHz | 66.11 ± 3.44 dB | 84.67 ± 2.15 dB | p < 0.0001 |
| 8 months | click | 68.24 ± 3.12 dB | 78.75 ± 1.25 dB | p = 0.0364 |
| 8 months | 4.1 kHz | 75.29 ± 4.47 dB | 88.75 ± 1.25 dB | p = 0.003 |
| 8 months | 8.2 kHz | 88.24 ± 0.95 dB | 85 ± 2.67 dB | ns |