Table 2.
Expression of c-Fos in the nuclei of the auditory pathway of 1.5-month-old wild-type (WT) and PACAP-deficient (KO) animals after noise exposure (noise) or without noise exposure (silent).
| Nucleus | WT silent | WT noise | KO silent | KO noise | p value | ||
|---|---|---|---|---|---|---|---|
| p1 | p2 | p3 | |||||
| VCN | 2.96 ± 0.32 | 52.95 ± 5.46 | 3.73 ± 0.36 | 21.47 ± 8.38 | p < 0.0001 | p = 0.0012 | p = 0.0214 |
| DCN | 3.68 ± 1.64 | 68.23 ± 11.43 | 2.83 ± 0.72 | 22 ± 1.73 | p < 0.0001 | p = 0.0042 | p = 0.0012 |
| MSO-LSO | 21.24 ± 3.99 | 63.97 ± 10.54 | 20.23 ± 7.11 | 87.6 ± 9.6 | p = 0.0096 | p = 0.0033 | ns |
| VMPN-VLPN | 26.24 ± 4.42 | 106.38 ± 11.8 | 32.50 ± 2.84 | 113.10 ± 5.90 | p < 0.0001 | p = 0.0007 | ns |
| NLL | 29.73 ± 4.16 | 75.61 ± 8.61 | 29.73 ± 4.95 | 89.35 ± 4.90 | p < 0.0001 | p < 0.0001 | ns |
| IC | 104.59 ± 13.8 | 697.6 ± 178.4 | 105 ± 33.66 | 671.33 ± 59.2 | p = 0.0019 | p = 0.0038 | ns |
| AU1 | 31.06 ± 4.90 | 49.85 ± 2.15 | 38.00 ± 6.21 | 52.09 ± 8.78 | ns | ns | ns |
Mean ± SEM. VCN, DCN: ventral and dorsal cochlear nuclei, MSO: medial superior olive, LSO: lateral superior olive, VMPN: ventromedial periolivary nucleus, VLPN: ventrolateral periolivary nucleus, NLL: nuclei of the lateral lemniscus, IC: inferior colliculus, AU1: primary auditory cortex; p1: WT noise vs. WT silent, p2: KO noise vs. KO silent, p3: KO noise vs. WT noise; ns = non-significant.