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. 2019 Oct 10;9:14515. doi: 10.1038/s41598-019-51078-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CD34/CD31 confocal immunofluorescence staining of paraffin-embedded tissue sections from control and eccentric contraction (EC)-damaged skeletal muscles. (A–F) Representative fluorescence images (A,C,E) and differential interference contrast (DIC) images (B,D,F) acquired simultaneously to allow a better appreciation of the tissue structure. (A) In control muscles, CD34⁺CD31⁻ telocytes (TCs) with distinctive long and thin varicose cytoplasmic prolongations (telopodes) are located in the interstitium alongside the myofibers and in the close vicinity of CD31⁺ vascular structures (arrow and higher magnification in the inset). (C,E) An extensive CD34⁺CD31⁻ TC meshwork is evident among myofibers in EC-damaged muscles. Insets: magnifications of the areas indicated by arrows; note the close vicinity of a CD34⁺CD31⁻ TC to a CD34⁺CD31⁺ blood capillary vessel (C), and a CD34⁺CD31⁻ spindle-shaped TC sending a distinctive moniliform telopode over long distance in the interstitial space among two myofibers (E). Images are representative of at least 6 sections from each of 5 control and 5 EC-injured muscles.