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. 2019 Oct 10;9:14493. doi: 10.1038/s41598-019-50769-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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RCFE inhibited metastatic properties of breast cancer cells. Inhibition of migration of MCF-7 (A) and MDA-MB-231 (B) with treatment of 0.05 and 0.1 µg/ml for 24 and 48 hr. The quantification of wound widths was shown in right panels. Data represent the mean ± SEM of three independent experiments. Statistical differences were analyzed with two-way ANOVA test. p value ns > 0.05, p value *** < 0.0001. Effect of RCFE on adhesion of MCF-7 (C) and MDA-MB-231 (D). Data represented as mean ± SEM of three independent experiments. Statistical differences were analyzed with one-way ANOVA test. p value < 0.05 was considered significant. Invasion of MCF-7 (E) and MDA-MB-231 (F) cells through ECM gel coated transwell inserts in response to RCFE. Data represent the mean ± SEM of five different images of individual set of three independent experiments (shown in right panels). Statistical differences were analyzed with student t-test. p value < 0.05 was considered significant. Western blot analysis of MMP-2 and -9 in MCF-7 (G) and MDA-MB-231 (H) cells in response to treatment with RCFE. The quantitation of band intensities was represented in bottom panels. Statistical differences were analyzed with one-way ANOVA test. p value < 0.05 was considered significant.