Figure 2.

ATM deficiency results in hyperactivation of the G₂-checkpoint when cells are irradiated in S-phase. (A) As in Fig. 1A for ATM deficient, AT5Biva cells exposed to 4 Gy and treated with indicated inhibitors. (B) As in Fig. 1C for AT5Biva cells exposed to 4 Gy and treated with indicated inhibitors. (C) As in Fig. 1A for 82-6 hTert cells exposed to 10 Gy and treated with the indicated inhibitors. (D) As in (C) for AT5Biva cells. All data points represent means and standard deviations (only visible when are larger than the symbol) estimated from three independent experiments.