Table 3.
Patients showing intra host quasispecies across compartments.
| Patient ID. | HBV Gene Region mutated | Reference position | Nucleotide detected in viral DNA from 3 host compartments | Amino acid (change) w.r.t. Ref | ||
|---|---|---|---|---|---|---|
| Plasma | B cell | Tumor Tissue | ||||
| 4 | Core | 2095 | G | A | NA | Arg94Leu |
| 10 | X | 1589 | C | A | NA | Arg72Arg |
| X | 1590 | T | G | Phe73Val | ||
| 11 | Core | 2318 | C | T | NA | Leu169Leu |
| X | 1590 | T | G | Phe73Val | ||
| 31 | Core | 2070 | A | G | — | Glu86Arg |
| 36 | X | 1504 | C | T | — | Ala44Val |
| 37 | X | 1809 | T | G | — | Ser146Ala |
| X | 1812 | T | C | — | Ser147Pro | |
| Precore | 1888 | A | G | — | Gly25Gly | |
| 38 | Core | 1934 | T | — | A | Ser41Thr* |
Amino acid abbreviations: Arginine (Arg), Leucine (Leu), Phenylalanine (Phe), Valine (Val), Glutamine (Glu), Alanine (Ala), Serine (Ser), Proline (Pro), Glycine (Gly), Threonine (Thr).
Ser41Thr* indicates a mis-sense mutant quasispecies at Core gene specifically in the tumor compartment where serine is substituted by threonine.