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. 2019 Oct 10;9:14516. doi: 10.1038/s41598-019-51157-1

Table 4.

Mutations in HBX amplicon sequences from Tumor tissue.

SN Mutation Type Domain
1 A1314G Upstream (−60) X promoter
2 A1320G Upstream (−54)
3 A1329A Upstream (−45)
4 T1335C Upstream (−39)
5 T1350C Upstream (−24)
6 T1353G Upstream (−21)
7 T1404C Ser11Pro Regulatory domain
8 A1437G Ser22Gly

S/P rich region

X binding region

9 C1450G Pro26Arg
10 G1464T Ala31Ser
11 A1467G Arg32Gly
12 G1479A Ala36Thr
13 G1482C Val37Leu
14 T1512G Ser47Ala
15 C1594T* Thr74Ile XAP1 binding Region
16 G1630A Arg86His
17 G1635A Val88Ile
18 T1762A Met130Lys p53 binding
19 A1764G Ile131Val
20 T1809G Ser146Ala
21 T1812C Ser147Pro

*Unique to patient 6. All other mutations were found in all seven FFPE samples analysed.

Amino acid abbreviations: Alanine (Ala), Arginine (Arg), Glycine (Gly), Histidine (His), Isoleucine (Ile), Leucine (Leu), Lysine (Lys) Methionine (Met), Proline (Pro), Serine (Ser), Threonine (Thr), Valine (Val).