Table 4.
Mutations in HBX amplicon sequences from Tumor tissue.
| SN | Mutation | Type | Domain |
|---|---|---|---|
| 1 | A1314G | Upstream (−60) | X promoter |
| 2 | A1320G | Upstream (−54) | |
| 3 | A1329A | Upstream (−45) | |
| 4 | T1335C | Upstream (−39) | |
| 5 | T1350C | Upstream (−24) | |
| 6 | T1353G | Upstream (−21) | |
| 7 | T1404C | Ser11Pro | Regulatory domain |
| 8 | A1437G | Ser22Gly |
S/P rich region X binding region |
| 9 | C1450G | Pro26Arg | |
| 10 | G1464T | Ala31Ser | |
| 11 | A1467G | Arg32Gly | |
| 12 | G1479A | Ala36Thr | |
| 13 | G1482C | Val37Leu | |
| 14 | T1512G | Ser47Ala | |
| 15 | C1594T* | Thr74Ile | XAP1 binding Region |
| 16 | G1630A | Arg86His | |
| 17 | G1635A | Val88Ile | |
| 18 | T1762A | Met130Lys | p53 binding |
| 19 | A1764G | Ile131Val | |
| 20 | T1809G | Ser146Ala | |
| 21 | T1812C | Ser147Pro |
*Unique to patient 6. All other mutations were found in all seven FFPE samples analysed.
Amino acid abbreviations: Alanine (Ala), Arginine (Arg), Glycine (Gly), Histidine (His), Isoleucine (Ile), Leucine (Leu), Lysine (Lys) Methionine (Met), Proline (Pro), Serine (Ser), Threonine (Thr), Valine (Val).